Ametik affects the areas of the brain that stimulate nausea and vomiting.
Ametik is used to treat nausea and vomiting related to surgery or caused by stomach flu.
Ametik may also be used for purposes not listed in this medication guide.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol.
Ametik® (Ametik injectable) is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
HOW SHOULD I USE AMETIK?
Use Ametik solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Ametik solution is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Ametik solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Ametik solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Ametik solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Ametik solution and you are taking it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Ametik solution.
USES OF AMETIK IN DETAILS
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form.
Use: Labeled Indications
Nausea/vomiting: Treatment of postoperative nausea and vomiting; treatment of nausea associated with gastroenteritis
Ametik is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with Ametik HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Oral, as hydrochloride:
Ametik: 300 mg
Generic: 300 mg
Intramuscular, as hydrochloride:
Ametik: 100 mg/mL (2 mL)
Ametik: 100 mg/mL (20 mL) [contains phenol]
Nausea/vomiting: Note: Use the lowest effective dosage based on response and tolerability.
IM: 200 mg 3 or 4 times daily
Oral: 300 mg 3 or 4 times daily
Refer to adult dosing; reduce the dose or increase the dosing interval and adjust as needed based on patient response.
Ametik may increase the side effects of other drugs that make you sleepy (such as cold medicine, pain medication, muscle relaxants, and medicine for seizures, depression or anxiety). Before using Ametik, tell your doctor if you are using any of these medicines.
There may be other drugs that can affect Ametik. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Note: Use in pediatric patients is strongly discouraged due to risk of EPS, serious CNS effects, and other adverse reactions. Expert recommendations for nausea and vomiting management do not suggest Ametik as a therapeutic option; use has been replaced by newer agents with an improved safety profile (MMWR 2003; SAA [Gan 2014]). Although rectal dosing may still be referred to in pediatric textbooks, rectal formulations of Ametik are no longer available.
Parenteral formulations are contraindicated in pediatric patients.
Nausea and vomiting, opioid induced: Limited data available (Kliegman 2016): Children and Adolescents:
Oral: 100 mg every 6 hours as needed
Oral: 200 mg every 6 hours as needed
AMETIK SIDE EFFECTS
Applies to Ametik: intramuscular solution, oral capsule
In addition to its needed effects, some unwanted effects may be caused by Ametik (the active ingredient contained in Ametik). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Ametik:
- Body spasm, with head and heels bent backward and body bowed forward
- convulsions (seizures)
- shakiness or tremors
- skin rash
- sore throat or fever
- unusual tiredness
- vomiting (severe or continuing)
- yellow eyes or skin
Minor Side Effects
Some of the side effects that can occur with Ametik may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
- Blurred vision
- muscle cramps
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Ametik overdose may include drowsiness, uncontrollable movements, muscle spasms, blurred vision, seizures or convulsions, difficulty breathing, and death.
Ametik may increase the side effects of other drugs that make you sleepy (such as alcohol, cold medicine, pain medication, muscle relaxants, and medicine for seizures, depression or anxiety). Before using Ametik, tell your doctor if you are using any of these medicines.
Ametik can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol while using Ametik. Alcohol can increase drowsiness and dizziness.
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